G protein-coupled receptors (GPCRs) are the largest family ofmembrane receptors that activate intracellular signalingcascades and undergo endocytosis, recycling, or degradationupon stimulation. The (mu) m-, delta (d) and kappa (k) opioid receptors areGPCRs of the nervous system, which control pain, stress, andaddictive behaviors. The delta opioid receptor (DOR-1) is the stereoselective receptor for enkephalins and inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.
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