TNFRSF1A is the receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor and the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNFRSF1A contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email firstname.lastname@example.org, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size Angiopoietin-1 (ANG-1) RA26000 100 ul Artemin RA19009 100 ul BDNF GT41014 100 ug CREB MO18006 100 ul Cripto RA25057 100 ul CYR61 RA25061 100 ul Enkephalin, pre-pro (ppENK) RA14124 50 ul FGF-2 MO27001 500 ug FOXD3 RA25044 100 ug GATA3 MO47046 100 ug GDNF Receptor Alpha 3 RA30017 50 ug Her2/Neu MO47003 100 ul IGF1R (Insulin-Like Growth Factor Receptor 1) RA21017 50 ug KDR (Kinase Insert Domain Receptor) RA21018 50 ug Kidins220 (ARMS) RA19019 100 ul Notch1 RA19069 100 ul Notch3 RA19070 100 ug PCNA MO20014 100 ul phospho-CREB (Ser133) RA18008 100 ul phospho-Kidins220 (ARMS) RA19020 100 ul phospho-TrkA(Tyr490) RA18018 100 ul pre-pro Enkephalin RA14142 50 ul PTGDS RA25023 100 ul RHEB RA30052 50 ug SMAD-2 RA21025 50 ug SMAD3 RA30033 50 ug TGF beta MO20012 100 ul. TGF beta RI (type1) MO20011 100 ul. Transforming Growth Factor (TGF) beta 1, middle region RA21028 50 ug VEGF R2 (FLK1/KDR) RA25011 100 ul VEGF R2 (FLK1/KDR) RA25011 500 ul VEGF R3 (Flt-4) MO20013 100 ul Wnt10a RA30027 50 ug Wnt2b RA30030 50 ug Wnt8a RA30029 50 ug