Product Details
Catalog Number: RA22109
Applications: ICC, WB
Type: Rabbit IgG
Dilutions: ICC 1:100-1:200; IHC 1:100-1:200; WB 1:250-1:500
Immunogen: Recombinant full length peripherin purified from E. coli.
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Whole serum
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Cat
Entrez: 5630
UniProt: P41219
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$275.00Add to Cart

Peripherin is a type III intermediate filament found initially in sensory neurons of the peripheral nervous system (PNS).  It serves as a marker for autonomic and sensory neurons in the PNS and motor neurons in the CNS. Peripherin is a diagnostic marker in amyotrophic lateral sclerosis and certain neuronally-derived tumors. Brain injuries can also trigger expression of peripherin and the formation of peripherin accumulations in neurons that are normally silent for this gene.

Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas.  Autoantibodies to peripherin are also frequently seen in the sera of patients with diabetes.

Images

Mixed neuron/glia cultures from newborn rat brain stained with peripherin (green) and phosphorylated NF-H (red). The blue channel reveals the localization of DNA.

Mixed neuron/glia cultures from newborn rat brain stained with peripherin (green) and phosphorylated NF-H (red). The blue channel reveals the localization of DNA.

Western blot of whole rat brain stem homogenate stained with Peripherin at a dilution of 1:20,000. A prominent band running with an apparent SDS-PAGE molecular weight of ~57kDa corresponds to Peripherin. A lower band at ~48kDa is derived from the Peripherin molecule.

Western blot of whole rat brain stem homogenate stained with Peripherin at a dilution of 1:20,000. A prominent band running with an apparent SDS-PAGE molecular weight of ~57kDa corresponds to Peripherin. A lower band at ~48kDa is derived from the Peripherin molecule.