Product Details
Catalog Number: RA22113
Applications: WB, IHC, IF
Type: Rabbit IgG
Immunogen: Purified human recombinant protein fragment structure from E. coli. corresponding to N terminal amino acids 1-100 of Human FOX3.
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Whole serum
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 146713
UniProt: A6NFN3
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$325.00Add to Cart

Fox3 is one of a family of 3 mammalian Fox homologues. Fox was discovered in C. elegans as a gene involved in sex determination, and the name Fox is an acronym of "Feminizing locus on X". The Fox protein and its 3 mammalian homologues are all about 46kDa proteins each of which includes a central highly conserved RRM type RNA recognition motif, which corresponds to a small ~70 amino acid structure consisting of 4 beta strands and two alpha-helices. An alternate name for Fox 3 is hexaribonucleotide binding protein 3, and these proteins are believed to have a role in the regulation of mRNA splicing.

Much interest has focused on Fox3 as this protein corresponds to NeuN, a neuronal nuclear antigen. NeuN antibody has become very widely used as a robust marker of neurons and neuronal stem cells. Fox3 is therefore a protein which has a funciton in RNA splicing and is expressed heavily and specifically in neuronal nuclei.

Images

FOX3 (red) staining of paraformaldehyde fixed frozen section of adult rat cortex. Counterstained for DNA in blue.

FOX3 (red) staining of paraformaldehyde fixed frozen section of adult rat cortex. Counterstained for DNA in blue.

FOX3 (red) staining of paraformaldehyde fixed frozen section of adult rat cortex. Counterstained for DNA in blue.

FOX3 (red) staining of paraformaldehyde fixed frozen section of adult rat cortex. Counterstained for DNA in blue.