Product Details
Catalog Number: RA22120
Applications: ICC, WB, IHC, IF
Type: Rabbit IgG
Immunogen: Full length human recombinant protein. HGNC name: CNP UniProtKB - P09543 (CN37_HUMAN)
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 1267
UniProt: P09543
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$325.00Add to Cart

CNP (2’, 3’-Cyclic Nucleotide 3’-Phosophodiesterase) has two isoforms, CNPase1 (46kDa) and CNPase2 (48kDa), which are encoded separately by different promoters of the same gene. CNP is found in high levels in the brain and peripheral nerve, almost exclusively in oligodendrocytes and Schwann cells. CNP is the third most abundant protein found in the central nervous system myelin. It is found early in oligodendrocyte development and continues to be found in adult animals. It may play a role in RNA metabolism in the myelinating cell. CNP antibody can be used as a marker for oligodendrocyte and Schwann cells. CNP levels have been found to greatly reduced in various diseases, neurological mutant and in experimental conditions in which myelin is reduced. Additionally, reduced CNP brain levels have been reported in Down syndrome and Alzheimer’s disease. 

Images
Mixed neuron-glial cell cultures stained with RA22120 (green) and our monoclonal antibody against GFAP (red, MO22136).

Mixed neuron-glial cell cultures stained with RA22120 (green) and our monoclonal antibody against GFAP (red, MO22136). The CNP antibody stains strongly in oligodendrocytes, whereas GFAP labels the intermediate filament in astrocytes. Blue is DNA staining showing the nuclei of these and numerous other cells, most of which are neurons and which do not express either CNP or GFAP.

Mixed neuron-glial cell cultures stained with RA22120 (green) and our monoclonal antibody against GFAP (red, MO22136).

Mixed neuron-glial cell cultures stained with RA22120 (green) and our monoclonal antibody against GFAP (red, MO22136). The CNP antibody stains strongly in oligodendrocytes, whereas GFAP labels the intermediate filament in astrocytes. Blue is DNA staining showing the nuclei of these and numerous other cells, most of which are neurons and which do not express either CNP or GFAP.