The protein proved to be an unusual member of the intermediate filament family, containing an α-helical region homologous to that found in keratin and neurofilament subunits. The Human Genome Organization (HUGO) Gene Nomenclature Committee (HGNC) name for Nestin is NES.
Nestin is relatively poorly conserved in protein sequence across species boundaries, so that the mouse and human proteins have an overall identity of only 62%. As a result antibodies to the human protein often fail to recognize the rodent homologue and vice versa. Antibodies to nestin are widely used to identify neural stem cells. This antibody was raised in rabbit against recombinant human nestin from aa 315-630, which has only 55% identity to homologous mouse sequence. Nestin (RA22125) therefore recognizes nestin protein in human, but not in rodent.
- Product Reviews
- Product Publications
- Carolina Pedrosa, Leticia Souza, et al. (2020). The Cyanobacterial Saxitoxin Exacerbates Neural Cell Death and Brain Malformations Induced by Zika Virus. PLoS Neglected Tropical Diseases. 14(3). doi: 10.1371/journal.pntd.0008060
- Livia Goto-Silva, Nadia M. E. Ayad, Iasmin L. Herzog, Nilton P. Silva, Bernard Lamien, Helcio R. B. Orlande, Annie da Costa Souza, Sidarta Ribeiro, Michele Martins, Gilberto B. Domont, Magno Junqueira, Fernanda Tovar-Moll and Stevens K. Rehen (2019). Computational fluid dynamic analysis of physical forces playing a role in brain organoid cultures in two different multiplex platforms. BMC Developmental Biology 201919:3 https://doi.org/10.1186/s12861-019-0183-y
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size α-Internexin/NF 66 MO22102 100ul α-Internexin/NF 66 MO22154 100 ul AP-2 Alpha RA18023 100 ul ATPase Na+/K+ transporting alpha 1 MO25023 50 ul Doublecortin/DCX MO22113 100 ul GAP43 CH22132 100 ul GAP43 MO22118 100 ul GAP43 MO22170 100 µl GAP43 RA25086 100 ul GAP43 (IgG) MO22171 100 µl Laminin RA25038 100 ul Laminin 111 RA22121 100 ul MSX1/HOX7 GT41015 100 ug Nestin CH22123 100 ul Nestin MO22183 100 ug Netrin-4 (NTN4) RA21023 50 ug Neurofilament alpha-internexin/NF66 CH22101 100 ul Neurofilament alpha-internexin/NF66 MO25017 500 ul Neurofilament alpha-internexin/NF66 RA22102 100 ul Notch1 RA19069 100 ul Notch3 RA19070 100 ug PAX-8 MO47029 100 ul PAX3 GT41025 100 ug Podoplanin MO47016 100 ul S-100 MO47059 100 ul SOX-2/SRY (sex determining region Y)-box 2 MO47038 100 ul SOX2 RA25021 100 ul SRY (Sex Determining Region Y)-Box 11/SOX-11 MO47052 100 ul Vimentin CH22108 100 ul Vimentin GT22103 100 ul Vimentin MO22115 100 ul Vimentin RA22124 100 ul of Serum