Galectin 3 is a member of a multigene family of 15 vertebrate lectins all of which share one or in some cases two “carbohydrate recognition domains” (CRD) which bind to β-galactoside, a sugar moiety found on many cell surface proteins. Much evidence suggests that Gal-3 has an important role in the regulation of inflammatory responses and fibrogenesis. In the brain it is expressed in microglia and certain astrocytes. Antibody to this protein can therefore be used to study inflammation within and outside the brain.
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