DJ1, also known as PARK7, is a soluble protein which belongs to the ThiJ/Pfp1/DJ1 superfamily. DJ1 was originally cloned as an oncogene that cooperatively transforms cells together with H-ras (1). Mutations in the DJ1 gene are associated with rare forms of autosomal recessive early-onset Parkinson’s disease (2). DJ-1 is a multifunctional protein that participates in transcriptional regulation, anti oxidative stress reaction, and chaperone, protease, and mitochondrial regulation. DJ1 may also function as an sensor for oxidative stress, and it protects neurons against oxidative stress and cell death (3-5). DJ-1 is expressed in almost all cells and tissues. DJ-1 is located in the cytoplasm, nucleus, and mitochondria in cells, and secreted DJ-1 has been observed in various cultured cells and tissues. Augmenting DJ1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson’s disease and acute damage such as stroke (6). The HGNC name for this protein is PARK7. The antibody was generated against full length recombinant human DJ1 protein expressed in and purified from E. coli. This antibody binds to the human, rat and mouse DJ1 proteins. The rodent protein is about 91% identical to the human protein.
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