The annexins are a large family of related proteins which share the property of binding to phophospholipid containing membranes in a Calcium dependent manner. Annexin A6 has a particularly surprising number of alternate names, 19 being listed on the Genecards ANXA6 site. Annexin A6 is normally localized in the cytosol but becomes membrane associated following cellular injury, and so is often seen in ““blebs”, transient herniations of the plasma membrane associated with apoptosis and more generally indicative of cell stress. Recent studies suggest that annexin A6 functions, in combination with annexin A4, in the repair of cell membranes following cellular injury.
RA22143 was made against full length recombinant human annexin A6 expressed in and purified from E. coli. The antibody recognizes annexin A6 in in human, rodents and many other mammals and can be used as a marker of blebs, indicative of cellular stress.
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