Product Details
Catalog Number: RA24287
Applications: WB, IHC
Type: Rabbit IgG
Dilutions: WB 1:500 - 1:1000
Immunogen: C-terminal synthetic peptide sequence corresponding to amino acids (1419-1433) of human nNos coupled to KLH.
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Whole serum
Format B: lyophilized
Species Reactivity: Human, Mouse, Rat, Primate, Guinea Pig, Cat
Entrez: 4842
UniProt: P29475
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 uL$375.00Add to Cart

Human nitric oxide synthases are a family of enzymes responsible for the synthesis of nitric oxide from L-arginine and molecular oxygen. There are at least three nitric oxide synthases; NOS I, also known as neuronal NOS or nNOS, NOS II, which is referred to as inducible NOS or iNOS and NOS III, also known as endothelial NOS or eNOS. nNOS plays a role in  the upregulation of microglial phospho-p38 MAPK. Such p38 MAPK activation in microglia is consistent with a potential role in the development of morphine antinociceptive tolerance.

nNOS is expressed in the hypothalamus, striatum, cortex, spinal cord and PNS. In ischemic stroke, nNOS activation is linked to Neural Damage.

Supporting Products
NameCatalog #Size
nNOS-C-terminus (Neuronal Nitric Oxide Synthase)P2428750 ug Blocking Peptide
Images

nNOS staining of rat brain

nNOS staining of rat brain