Product Details
Catalog Number: RA24600
Applications: WB, IHC, IF
Type: Rabbit IgG
Immunogen: Dopamine beta-Hydroxylase purified from bovine adrenal medulla.
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Whole serum
Format B: lyophilized
Species Reactivity: Mouse, Rat, Bovine
Entrez: 1621
UniProt: P09172
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$399.00Add to Cart

Regulation of gene expression of dopamine beta hydroxylase (DBH) and tyrosine hydroxylase (TH), two of the catecholamine biosynthetic enzymes, by cyclic AMP, diacyl glycerol, and Ca2+ leads to increased neurotransmitter biosynthesis.

Dopamine beta-hydroxylase catalyzes the conversion of dopamine to noradrenaline and is expressed selectively in noradrenergic and adrenergic neurons in the nervous system. The disruption of the DBH gene is thought to cause changes in development and behavior in certain models. Both DBH and the multiple regulatory pathways of DBH are of increasing research in many neurological diseases.

Images

Staining of DBH positive neurons in rat brainstem.

Staining of DBH positive neurons in rat brainstem.