Product Details
Catalog Number: RA25011
Applications: IHC
Type: Rabbit IgG
Immunogen: Synthetic peptide derived from the C-terminus of the precursor form of the mouse VEGFR 2.
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Protein A purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 3791
UniProt: P35968
Downloads: SDS (pdf)
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ul$139.00Add to Cart
500 ul$430.00Add to Cart

VEGF receptor 2 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signalling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity.

Images

VEGF R2 Staining in FFPE human angiosarcoma

VEGF R2 Staining in FFPE human angiosarcoma