The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer’s disease.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size Angiopoietin-1 (ANG-1) RA26000 100 ul Artemin RA19009 100 ul BDNF GT41014 100 ug CREB MO18006 100 ul CYR61 RA25061 100 ul FGF-2 MO27001 500 ug GATA3 MO47046 100 ug GDNF Receptor Alpha 3 RA30017 50 ug Her2/Neu MO47003 100 ul IGF1R (Insulin-Like Growth Factor Receptor 1) RA21017 50 ug KDR (Kinase Insert Domain Receptor) RA21018 50 ug Kidins220 (ARMS) RA19019 100 ul Notch1 RA19069 100 ul Notch3 RA19070 100 ug PCNA MO20014 100 ul phospho-Kidins220 (ARMS) RA19020 100 ul phospho-TrkA(Tyr490) RA18018 100 ul pre-pro Enkephalin RA14142 50 ul RHEB RA30052 50 ug SMAD-2 RA21025 50 ug SMAD3 RA30033 50 ug TGF beta MO20012 100 ul. TGF beta RI (type1) MO20011 100 ul. TNFRSF1 (Tumor Necrosis Factor Receptor Superfamily, Member 1A), N terminal region RA21029 50 ug Transforming Growth Factor (TGF) beta 1, middle region RA21028 50 ug VEGF R2 (FLK1/KDR) RA25011 100 ul VEGF R2 (FLK1/KDR) RA25011 500 ul VEGF R3 (Flt-4) MO20013 100 ul Wnt10a RA30027 50 ug Wnt2b RA30030 50 ug Wnt8a RA30029 50 ug