Product Details
Catalog Number: RA25026
Applications: WB, IHC
Type: Rabbit IgG
Immunogen: A synthetic peptide made to a region within the N-terminus of the human XCT protein sequence (between residues 1-50).
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Entrez: 23657
UniProt: Q9UPY5
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$429.00Add to Cart

Mammalian amino acid transport systems consist of a large variety of transporters. The amino acid transporter, cystine/glutamic acid transporter xCT, for system xc has been proposed to be responsible for the cystine transport through the plasma membrane. System xc mediates an amino acid exchange and prefers cystine and glutamate as its substrates. The transporter designated as xCT requires 4F2 heavy chain (4F2hc:CD98) for its functional expression, and belongs to the family of amino acid transporters that associates with the type II membrane glycoproteins such as 4F2hc. In brain, it has been proposed that system xc is up-regulated in glial cells upon oxidative stress and plays an essential roles to protect neurons against oxidative stress. Recent studies have implicated xCT as a gateway that Kaposi's sarcoma herpesvirus (KSHV) uses to enter cells.

Images

XCT staining in the absorptive epithelia of intestinal villi.

XCT staining in the absorptive epithelia of intestinal villi.

Detection of XCT in total human and mouse stomach lysate.

Detection of XCT in total human and mouse stomach lysate.