Using anti-Yo antibodies, three genes have been cloned (CDR 1-3). CDR2 Cerebellar degeneration related protein 2) suppresses the transcriptional activity and DNA binding of nuclear factor-kappa B by an unknown mechanism. The neuron specific expression of CDR2 is regulated by a post-transcriptional mechanism.
CDR2 is an onconeuronal antigen; i.e. an antigen that is expressed by systemic tumors and elicits an immune response that may develop into an autoimmune neuronal degeneration. Paraneoplastic cerebellar degeneration (PCD) is a disorder in which breast or ovarian tumors express CDR2, which normally is expressed in cerebellar Purkinje neurons.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size BACE1 RA21010 50 ug Beta-Synuclein MO22199 100 ul Beta-Synuclein RA22141 100 ul GABA A receptor alpha 4 GT41008 100 ug GABA A Receptor beta 3 GT41011 100 ug GABA Receptor Associated Protein RA19014 100 ug GluR2/AMPA2 RA30012 50 ug GluR4/AMPA4 GT41012 100 ug Nicotinic acetylcholine receptor alpha7 GT41009 100 ug NMDA NR1 Pan MO25041 15 ug NMDA Receptor 1, N1 RA25036 25 ug NMDA Receptor 2A RA25037 100 ul NMDA Receptor 2B RA25063 100 ul P2X1 RA10107 150 ul P2X1 RA10107 50 ul P2X2 GP14106 150 ul P2X2 GP14106 50 ul P2X2 RA10108 150 ul P2X2 RA10108 50 ul P2X3 GP10108 100 ul P2X3-Pure RA14139 100 ul p504s/AMACR (α-Methylacyl Coenzyme A Racemase) MO47014 100 ul phospho-NMDA Receptor 1 (Ser890) RA18011 100 ul Phospho-NMDA Receptor 1 (Ser896) RA18012 100 ul PSAP (Prostatic Specific Acid Phosphatase)/PAP MO47053 100 ul S-100 MO47059 100 ul