Product Details
Catalog Number: RA25048
Applications: WB, IHC
Type: Rabbit IgG
Immunogen: A synthetic peptide made to a C-terminal region of the human CDR2 protein. [Swiss-prot# Q01850].
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Primate, Bovine
Entrez: 1039
UniProt: Q01850
Downloads: SDS (pdf)
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$379.00Add to Cart

Using anti-Yo antibodies, three genes have been cloned (CDR 1-3). CDR2 Cerebellar degeneration related protein 2) suppresses the transcriptional activity and DNA binding of nuclear factor-kappa B by an unknown mechanism. The neuron specific expression of CDR2 is regulated by a post-transcriptional mechanism.

CDR2 is an onconeuronal antigen; i.e. an antigen that is expressed by systemic tumors and elicits an immune response that may develop into an autoimmune neuronal degeneration. Paraneoplastic cerebellar degeneration (PCD) is a disorder in which breast or ovarian tumors express CDR2, which normally is expressed in cerebellar Purkinje neurons.

Images

CDR2 staining of Purkinje neurons in the Human cerebellum

CDR2 staining of Purkinje neurons in the Human cerebellum

Detection of CDR2 in HeLa whole cell lysates.

Detection of CDR2 in HeLa whole cell lysates.