Product Details
Catalog Number: RA25068
Applications: WB, IHC
Type: Rabbit IgG
Immunogen: Synthetic peptide made to an internal portion of the human protein (within residues 500-550). [Swiss-Prot# P01130]
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Entrez: 3949
UniProt: P01130
Downloads: Datasheet (pdf)
Downloads: SDS (pdf)
Product Sizes
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100 ul$429.00Add to Cart

The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis (1). Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits (2). It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by LDL receptors on cultured cells.

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Detection of LDL R by Western Blot

Detection of LDL R by Western Blot