Product Details
Catalog Number: RA25083
Applications: ICC, WB, IF
Type: Rabbit IgG
Immunogen: A synthetic peptide made to an internal region (within residues 1-100) of the human Bmi1 protein. [Swiss-Prot# P35226].
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Primate, Chicken, Rabbit, Bovine, Cat, Zebrafish
Entrez: 648
UniProt: P35226
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$379.00Add to Cart

Bmi1 induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. It has also been termed an oncogene with aberrant expression in various carcinomas. It has been shown to be a negative regulator of p19Arf, Ink4a (p14Arf) and tp53 known tumor repressors. Ablation of Bmi1 is required for short term survival of cancer cells.

In addition, Bmi1 expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation.

Images

Bmi1 staining in Hela cells.

Bmi1 staining in Hela cells.

Detection of Bmi1 protein in skeletal muscle.

Detection of Bmi1 protein in skeletal muscle.