Product Details
Catalog Number: RA30040
Applications: WB, IHC, E
Type: Rabbit IgG
Immunogen: 17 amino acid synthetic peptide from near the carboxy terminus of human PARC.
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 23113
UniProt: Q8IWT3
Downloads: Datasheet (pdf)
Product Sizes
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50 ug$435.00Add to Cart

PARC (p53 associated parkin like cytoplasmic protein) antibody directly interacted and formed an approximately 1MD complex with p53 in the cytoplasm of unstressed cells. In the absence of stress, inactivation of PARC induced nuclear localization of endogenous p53 and activated p53 dependent apoptosis. Overexpression of PARC promoted cytoplasmic sequestration of ectopic p53. Furthermore, abnormal cytoplasmic localization of p53 was observed in a number of neuroblastoma cell lines; RNA interference-mediated reduction of endogenous PARC significantly sensitized these neuroblastoma cells in the DNA damage response. These results revealed that PARC is a critical regulator in controlling p53 subcellular localization and subsequent function.

Images

Human testis: Formalin-Fixed Paraffin-Embedded (FFPE).

Human testis: Formalin-Fixed Paraffin-Embedded (FFPE).