Product Details
Catalog Number: SO25000
Applications: ICC, WB, IHC, IF
Type: Sheep IgG
Dilutions: ICC 1:100-1:200; IHC 1:100-1:200; WB 1:250-1:500
Immunogen: Native rat tyrosine hydroxylase purified from pheochromocytoma.
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Primate
Entrez: 7054
UniProt: P07101
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$450.00Add to Cart

Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation of the TH enzyme represents the central means for controlling the synthesis of these important catecholamines. TH has a large molecular diversity, resulting from differential splicing of its mRNA, which is tissue specific and might result in long-term changes in activity of the enzyme and the availability of neurotransmitter at various synapses. 

The presence of different DNA sequences at the TH locus confers susceptibility to various disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency, as low dopamine levels are a consistent neurochemical abnormality.

Images
TH staining of neurons in the mouse SNc.

TH staining of neurons in the mouse SNc.

TH staining of neurons in the mouse SNc.

TH staining of neurons in the mouse SNc.

Detection of tyrosine hydroxylase in PC12 cell lysate by Western Blot. Band is at approximately 60 kDa

Detection of tyrosine hydroxylase in PC12 cell lysate by Western Blot. Band is at approximately 60 kDa.

Detection of tyrosine hydroxylase in PC12 cell lysate by Western Blot. Band is at approximately 60 kDa

Detection of tyrosine hydroxylase in PC12 cell lysate by Western Blot. Band is at approximately 60 kDa.