Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation of the TH enzyme represents the central means for controlling the synthesis of these important catecholamines. TH has a large molecular diversity, resulting from differential splicing of its mRNA, which is tissue specific and might result in long-term changes in activity of the enzyme and the availability of neurotransmitter at various synapses.
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- Tanvi Paretkar (2018). The Central Amygdala Corticotrophin-Releasing Hormone (CRH) Neurons Modulation of Anxiety-Like Behavior and Hippocampus-Dependent Memory in Mice. (Doctoral Dissertation) Rosalind Franklin University.
- Eugene L. Dimitrov, Jonathan Kuo, Kenji Kohno, and Ted B. Usdin. (2013). Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues. PNAS, doi: 10.1073/pnas.1306342110
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