Substance P is a neuropeptide derived from preprotachinin. Substance P is widely distributed in the central and peripheral nervous system. In sensory ganglia, it is expressed by small sensory neurons and is transported to their central and peripheral terminals. The role of substance P in sensory transmission has been studied extensively, and its involvement in nociception and chronic pain is well established. Our guinea pig anti-substance P antibody provides an excellent tool for multicolor immunofluorescence experiments.
- Product ReviewsThe product was very satisfactory. I recommend everyone to purchase from Neuromics.Prabesh Ghimire - Mar 22, 2018 - Rating: 5.0Your guinea pig substance P antibody works great for IHC. Product Name: Substance P, Guinea Pig – (Cat# GP14103) http://bit.ly/1FvXVCx Organization: UPENNChristine - Mar 21, 2015 - Rating: 5.0
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- Product Publications
- Khaled Abdallah, Francis Nadeau, Francis Bergeron, Sylvie Blouin, Véronique Blais, Kelly M. Bradbury, Christine L. Lavoie, Jean-Luc Parent & Louis Gendron. (2018). Adeno-associated virus 2/9 delivery of Cre recombinase in mouse primary afferents. Scientific Reports volume 8, Article number: 7321 (2018) doi:10.1038/s41598-018-25626-y
- Chien-Cheng Liu, Yong-Jing Gao, Hao Luo, Temugin Berta, Zhen-Zhong Xu, Ru-Rong Ji & Ping-Heng Tan. (2016). Interferon alpha inhibits spinal cord synaptic and nociceptive transmission via neuronal-glial interactions. Scientific Reports, 6, Article number: 34356. doi: 10.1038/srep34356
- Leanne M. Ramer, A. Peter van Stolk, Jessica A. Inskip, Matt S. Ramer and Andrei V. Krassioukov. (2012). Plasticity of TRPV1-expressing sensory neurons mediating autonomic dysreflexia following spinal cord injury. Front. Physiol., doi: 10.3389/fphys.2012.00257
- Tong Liu, Temugin Berta, Zhen-Zhong Xu,Chul-Kyu Park,Ling Zhang, Ning Lü, Qin Liu, Yang Liu, Yong-Jing Gao, Yen-Chin Liu, Qiufu Ma, Xinzhong Dong, and Ru-Rong Ji. (2012). TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. J Clin Invest. 122(6): 2195–2207. doi: 10.1172/JCI45414
- Xiaoyang Zhang, Kristy L.Douglas, Huixia Jin, Bassem M. Eldaif, Rashid Nassar, Matthew O. Fraser, and Paul C. Dolber. (2008). Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury. Am J Physiol, 295: R2084-R2096. doi: 10.1152/ajpregu.90653.2008
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