PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers.
It was also discovered as a gene mutated in some rare famial forms of Parkinson's disease. Interestingly a common allelic variant of UCHL1, the S18Y polymorphism is actually protective against Parkinson's disease. It is also a marker for cells of the diffuse neuroendocrine system and their tumors.
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- Andrea Nestor-Kalinoski, Kristen M. Smith-Edwards, Kimberly Meerschaert, Joseph F. Margiotta, Bartek Rajwa, Brian M. Davis, Marthe J. Howard. (2021). Unique Neural Circuit Connectivity of Mouse Proximal, Middle and Distal Colon Defines Regional Colonic Motor Patterns. Cellular and Molecular Gastroenterology and Hepatology. doi: 10.1016/j.jcmgh.2021.08.016
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- Marina Avetisyan, Hongtao Wang, Ellen Merrick Schill, Saya Bery, John R. Grider, John A. Hassell, Thaddeus Stappenbeck, and Robert O. Heuckeroth. (2015). Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury. The Journal of Neuroscience, 35(33): 11543-11558; doi: 10.1523/JNEUROSCI.5267-14.2015
- Julie K. Watson, Steffen Rulands, Adam C. Wilkinson, Aline Wuidart, Marielle Ousset, Alexandra Van Keymeulen, Berthold Gottgens, Ce´dric Blanpain, Benjamin D. Simons, and Emma L. Rawlins. (2015). Clonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow-Turnover Airway Epithelium. Cell Reports 12, 1–12. doi: 10.1016/j.celrep.2015.06.011
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- Aya Fukudaa, Tetsuya Gotob, Kayoko N. Kuroishia, Kaori K. Gunjigakea, Shinji Kataokab, Shigeru Kobayashib, Kazunori Yamaguchia. (2013). Hemokinin-1 competitively inhibits substance P-induced stimulation of osteoclast formation and function. Neuropeptides, Volume 47, Issue 4, Pages 251–259. doi: 10.1016/j.npep.2013.04.001
- Ichiki, Takako, Kuroishi, Kayoko N., Gunjigake, Kaori K., Kobayashi, Shigeru, Goto, Tetsuya. (2011). Neurokinin B activates the formation and bone resorption activity of rat osteoclasts. Neuropeptides, doi: 10.1016/j.npep.2011.03.006
- K. Czaja, G.A. Burns, and R.C. Ritter. (2008). Capsaicin-induced neuronal death and proliferation of the primary sensory neurons located in the nodose ganglia of adult rats. Neuroscience, 154(2): 621–630. doi: 10.1016/j.neuroscience.2008.03.055
- Jason E. Wells PhD, Edward T. Rose, Kevin C. Rowland PhD, and John F. Hatton DMD. (2007). Kv1.4 Subunit Expression is Decreased in Neurons of Painful Human Pulp. Journal of Endodontics, doi: 10.1016/j.joen.2007.03.013
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