The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain. They are involved in the regulation of embryonic development and in the determination of cell fate.
SOX2 belongs to the SOX (SRY-like HMG box) family of transcription factors with diverse roles in development. SOX2 functions in specifying the first three lineages present at implantation and in regulating proliferation and differentiation in the developing peripheral nervous system.
- Product ReviewsNo problems, great communication and fast shipping. Will definitely continue to patronize in the future. Product Name: SOX2, Goat – (Cat# GT15098) http://bit.ly/1kXZMpw Organization: Massachusetts General HospitalCaitlin Murphy - Oct 19, 2015 - Rating: 5.0Very pleasant customer service, accurate and fast product delivery. Product Name: SOX2, Goat – (Cat# GT15098) http://bit.ly/1kXZMpw Organization: University of MichiganLaura - Mar 15, 2014 - Rating: 5.0
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- Product Publications
- Masashi Higuchi, Saishu Yoshida, Naoko Kanno, Hideo Mitsuishi, Hiroki Ueharu, Mo Chen, Naoto Nishimura, Takako Kato, Yukio Kato. (2017). Clump formation in mouse pituitary-derived non-endocrine cell line Tpit/F1 promotes differentiation into growth-hormone-producing cells. Cell Tissue Res, doi: 10.1007/s00441-017-2603-2
- Hiroki Ueharu, Saishu Yoshida, Takako Kikkawa, Naoko Kanno, Masashi Higuchi, Takako Kato, Noriko Osumi, & Yukio Kato. (2016). Gene tracing analysis reveals the contribution of neural crest-derived cells in pituitary development. Journal of Anatomy. doi: 10.1111/joa.1257
- Kotaro Horiguchi, Hideji Yako, Saishu Yoshida, Ken Fujiwara, Takehiro Tsukada, Naoko Kanno, Hiroki Ueharu, Hiroto Nishihara, Takako Kato, Takashi Yashiro, Yukio Kato. (2016). S100β-Positive Cells of Mesenchymal Origin Reside in the Anterior Lobe of the Embryonic Pituitary Gland. PLOS One. doi: 10.1371/journal.pone.0163981
- Elisa Garbayoa, Eduardo Ansorenab, Hugo Lanaa, María del Mar Carmona-Abelland, Irene Marcillae, José Luis Lanciegob, María Rosario Luquinb, María José. Blanco-Prietoa. (2016). Brain delivery of microencapsulated GDNF induces functional and structural recovery in parkinsonian monkeys. Biomaterials, doi: 0.1016/j.biomaterials.2016.09.015
- Hitoshi Niwa, Akira Nakamura, Makoto Urata, Maki Shirae-Kurabayashi, Shigehiro Kuraku, Steven Russell and Satoshi Ohtsuka. (2016). The evolutionally-conserved function of group B1 Sox family members confers the unique role of Sox2 in mouse ES cells. BMC Evolutionary Biology, doi: 10.1186/s12862-016-0755-4
- Naoko Kanno, Masashi Higuchi, Saishu Yoshida, Hideji Yako, Mo Chen, Hiroki Ueharu, Naoto Nishimura, Takako Kato, Yukio Kato. (2015). Expression studies of neuronatin in prenatal and postnatal rat pituitary. Cell and Tissue Research, pp 1-16, doi: 10.1007/s00441-015-2325-2
- S. Yoshida, T. Kato1, H. Yako, T. Susa, L.-Y. Cai, M. Osuna, K. Inoue and Y. Kato. (2011). Significant Quantitative and Qualitative Transition in Pituitary Stem/Progenitor Cells Occurs during the Postnatal Development of the Rat Anterior Pituitary. Journal of Neuroendocriniology, 23, 933–943
- O Leis, A Eguiara, E Lopez-Arribillaga, M J Alberdi, S Hernandez-Garcia, K Elorriaga, A Pandiella, R Rezola and A G Martin. (2012). Sox2 expression in breast tumours and activation in breast cancer stem cells. Oncogene, doi: 10.1038/onc.2011.338
- Marc R. Del Bigio. (2011). Cell proliferation in human ganglionic eminence and suppression after prematurity-associated haemorrhage Brain. Brain, doi: doi:10.1093/brain/awr052
- Angel C.Y. Mak, Irene Y.Y. Szeto, Bernd Fritzsch and Kathryn S.E. Cheah. (2009). Differential and overlapping expression pattern of SOX2 and SOX9 in inner ear development. Gene Expression Patterns, doi: 10.1016/j.gep.2009.04.003.
- Trond Aasen, Angel Raya, Maria J Barrero, Elena Garreta, Antonella Consiglio, Federico Gonzalez, Rita Vassena, Josipa Bili, Vladimir Pekarik, Gustavo Tiscornia, Michael Edel, Stéphanie Boué & Juan Carlos Izpisúa Belmonte. (2008). Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nature Biotechnology 26, 1276 - 1284. doi: 10.1038/nbt.1503
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