Selector resins are based on high-affinity single-domain antibodies (sdAb) which are covalently immobilized on 4% cross-linked agarose beads. The oriented and selective attachment via a flexible linker guarantees a high accessibility of the sdAbs and largely eliminates batch-to-batch variations. Due to the single-chain nature of sdAbs and their covalent attachment, no "leakage" of light and heavy chains from IgGs is observed during elution with SDS sample buffer.
Key Benefits of Selector Resins
- High capacity
- Minimal unspecific binding
- No co-elution of heavy and light chain
- Broad buffer compatibility for high flexibility