Calbindin is a calcium-binding protein belonging to the troponin C superfamily. It functions as a buffer of cytosolic calcium and is found in the brain, kidney, gut and pancreatic islets. In normal brain, calbindin (28kD) has been identified in medium sized neurons of the neuropil of the matrix compartment of the striatum, the woolly fiber arrangements of the globus pallidus and the fiber structures of the pars reticula of the substantia nigra.
Image: Calbindin staining of Human brain, cerebellum. Note cytoplasmic staining of Purkinje cells and neuronal processes. Paraffin section.
The normal expression of calbindin is modified in patients with progressive supranuclear palsy, striatal degeneration and Huntington's disease (HD). In HD, alterations to the dendritic arbors and spiny striatal neurons may be visualized by immunohistochemistry for calbindin. In moderate grades of HD, proliferative changes have been found in these areas and in severe grades, degenerative changes have been noted. A proportion of dendritic cells within the light zone of germinal centers are also noted to be positive for calbindin.
Calbindin, via the ventrolateral periaqueductal gray (vlPAG), is thought to play a role in the reactions characteristic of deep pain.
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Name Catalog # Calretinin CH22116 Calbindin CH22118 S100B GT15160 VAMP-1 GT15236 CaMKII2A GT41019 Neurogranin precursor GT41024 Calcineurin A MO15055 Calbindin D MO15097 Synaptotagmin 1 MO15099 Calretinin MO20024 Calreticulin MO22164 Calretinin (IgG1) MO22165 Calretinin MO22166 Cav1.2 Ca2+ channel MO50006 Cav1.3 Ca2+ channel MO50007 Cav3.1 Ca2+ channel MO50008 Bradykinin Receptor B2 RA14137 CaMKII RA18006 phospho-Synapsin (Ser9) RA18009 Synapsin RA18010 SHANK1a N-Terminus RA19015 SHANK1a C-terminus RA19016 MARCKS (Myristoylated Alanine Rich C Kinase Substrate) RA22111 Striatin RA25067 CADM1/SynCAM RA25084