Calretinin (CAL6). a member of the family of so-called EF-hand proteins that also includes S-100 proteins, is a 29 kDa calcium binding protein that is expressed in central and peripheral nervous system and in many normal and pathological tissues.
Outside the nervous system, calretinin is reported to be expressed in a range of cell types including mesothelial cells, steroid producing cell, (eg adrenal cortical cells, Leydig cells, ovarian theca interna cells as well as Sertoli cells, some neuroendocrine cells, eccrine sweat glands) and other cell types.
Image: Calretinin staining of human mesotheliom. Note cytoplasmic staining of malignant cells. Paraffin section.
The presence of calretinin is reported to be a useful marker primarily for differentiating malignant mesothelioma from carcinomas. Other reports indicate the detection of calretinin is helpful for the differential characterization of ovarian stroma tumors. Calretinin-positive cells have also been reported in the convoluted tubules of kidney with some antibodies.
- Product Reviews
- Related Products
Name Catalog # Calretinin CH22116 Calbindin CH22118 S100B GT15160 VAMP-1 GT15236 CaMKII2A GT41019 Neurogranin precursor GT41024 Calcineurin A MO15055 Calbindin D MO15097 Synaptotagmin 1 MO15099 Calbindin MO20016 Calreticulin MO22164 Calretinin (IgG1) MO22165 Calretinin MO22166 Cav1.2 Ca2+ channel MO50006 Cav1.3 Ca2+ channel MO50007 Cav3.1 Ca2+ channel MO50008 Bradykinin Receptor B2 RA14137 CaMKII RA18006 phospho-Synapsin (Ser9) RA18009 Synapsin RA18010 SHANK1a N-Terminus RA19015 SHANK1a C-terminus RA19016 MARCKS (Myristoylated Alanine Rich C Kinase Substrate) RA22111 Striatin RA25067 CADM1/SynCAM RA25084