Product Details
Catalog Number: MO25010
Applications: WB, IHC, E
Type: Mouse IgG
Immunogen: Native PGP 9.5 protein from brain.
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Bovine, Porcine
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ul$475.00Add to Cart

PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers.

It was also discovered as a gene mutated in some rare famial forms of Parkinson's disease. Interestingly a common allelic variant of UCHL1, the S18Y polymorphism is actually protective against Parkinson's disease. It is also a marker for  cells of the diffuse neuroendocrine system and their tumors.

Customer Testimonial and Image: The PGP mouse that we received from Neuromics works fantastically!  I used it at 1:100 with Cy3 at 1:500 and got great staining with good background levels. PGP9.5 staining of  Rat Abdominal Tissue. Courtesy of Jamie Nugent (Dr. Marna Ericson's Lab), University of Minnesota.