PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers.
It was also discovered as a gene mutated in some rare famial forms of Parkinson's disease. Interestingly a common allelic variant of UCHL1, the S18Y polymorphism is actually protective against Parkinson's disease. It is also a marker for cells of the diffuse neuroendocrine system and their tumors.
Customer Testimonial and Image: The PGP mouse that we received from Neuromics works fantastically! I used it at 1:100 with Cy3 at 1:500 and got great staining with good background levels. PGP9.5 staining of Rat Abdominal Tissue. Courtesy of Jamie Nugent (Dr. Marna Ericson's Lab), University of Minnesota.
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Name Catalog # CGRP CH14100 Neurotensin Receptor 1 (NTS1) CH14110 ACE/CD143 FC15000 Neurotensin Receptor 1 (NTS1) GP14020 Substance P GP14103 PGP9.5 175-191 GP14104 ppNPY GP14107 Neuropeptide Q2/NPQ2 GP14109 Substance P-Pure GP14110 Agouti-Related Protein GT15023 Agouti-Related Protein (Human) GT15040 ACE/CD143 GT15145 Neurotensin Receptor 3 (NTS3)/Sortilin GT15237 Substance P MO15094 Orexin B MO15114 PGP9.5 MO20002 PGP9.5 RA12103 NPY Y2 Receptor RA14112 Enkephalin, pre-pro (ppENK) RA14124 Neuropeptide Q/NPQ RA14131 Neuropeptide Q3/NPQ3 RA14134 NPY Y2 Receptor-C/N Terminus RA14136 CCK A Receptor RA15049 Neurotensin Receptor 2 (NTS2) RA17100 Neuropeptide FF1 Receptor RA19017 Neuropeptide FF2 Receptor RA19018 FMRFamide RA20002 Substance P RA20064 VIP RA20077 CCK-8 (Cholecystokinin Octapeptide) RA20078 beta-Lipotropin RA21003 Met-Enkephalin RA21006 Leu-Enkephalin RA21007 CGRP RA24112 NPY Y1 Receptor RA24506 NPY RA24603 Neurokinin-1 (NK 1) Receptor RA25001 Neurokinin-3 (NK 3) Receptor RA25002 Neurokinin-1 (NK 1) Receptor RA25003 Somatostatin Receptor-1-SSTR1 RA25004 Somatostatin Receptor-2-SSTR2 RA25005 proNeurokinin B (proNKB or P2) RA25008 Neurokinin-2 (NK 2) Receptor RA30006