Product Details
Catalog Number: RA14132
Applications: IHC, FC, IF
Type: Rabbit IgG
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$350.00Add to Cart

c-Kit is transmembrane tyrosine kinase encoded by the c-Kit proto oncogene. c-Kit acts to regulate a variety of biological processes including cell proliferation, apoptosis, chemotaxis and adhesion.
It plays a critical role in activation and growth in a number of cell types such as hematopoietic stem cells, mast cells, melanocytes and germ cells.

Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.