c-Kit is transmembrane tyrosine kinase encoded by the c-Kit proto oncogene. c-Kit acts to regulate a variety of biological processes including cell proliferation, apoptosis, chemotaxis and adhesion.
Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.
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- Marit Inngjerdingen, Lise Kveberg and John T. Vaage. (2012). A Novel NKR-P1Bbright NK Cell Subset Expresses an Activated CD25+CX3CR1+CD62L−CD11b−CD27− Phenotype and Is Prevalent in Blood, Liver, and Gut-Associated Lymphoid Organs of Rat. The Journal of Immunology, doi: 10.4049/jimmunol.1003939
- Karim Harhouri, Abdeldjalil Kebir, Benjamin Guillet, Alexandrine Foucault-Bertaud, Serge Voytenko, Marie-Dominique Piercecchi-Marti, Caroline Berenguer, Edouard Lamy, Frédéric Vely, Pascale Pisano, L'Houcine Ouafik, Florence Sabatier, José Sampol, Nathalie Bardin, Françoise Dignat-George, and Marcel Blot-Chabaud. (2010). Soluble CD146 displays angiogenic properties and promotes neovascularization in experimental hind-limb ischemia. Blood, 115: 3843 - 3851. doi: 10.1182/blood-2009-06-229591
- Kalam K. Chan, Danna M. Breen, Jiwanjeet K. Dhaliwall, Michael R. Ward, Nael Al Koudsi, Loretta Lam, Melissa De Souza, Husam Ghanim, Paresh Dandona, Duncan Stewart, Michelle P. Bendeck, and Adria Giacca. Insulin Increases Reendothelialization and Inhibits Cell Migration and Neointimal Growth After Arterial Injury. Arteriosclerosis, Thrombosis, and Vascular Biology, doi: 10.1161/ATVBAHA.109.185447
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