Bradykinin Receptor B2 (BDKRB2) is associated with G proteins that activate a phosphatidylinositol-calcium second messenger It mediates smooth muscle contraction, induces relaxation of arteries, and stimulates diuresis. In addition, bradykinin B2 receptor has been implicated in inflammation and response to pain. This receptor is encoded by a single-copy gene. Two variants are produced by alternate start codons. Bradykinin B2 receptor expression has been reported in blood, brain, eye, kidney, liver, lung, prostate, skin, small intestine, synovium, uterus, and vessel. ESTs have been isolated from colon, connective tissue, heart, heart/melanocyte/uterus, kidney, lung, placenta, and thyroid libraries
Image: Immunofluorescent detection of Bradykinin R2 in rat brain using Cy3 conjugated anti-rabbit secondary antibodies (red fluorescence).
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