Product Details
Catalog Number: RA18021
Applications: WB, IP
Type: Rabbit IgG
Immunogen: Peptide derived from the carboxy-terminal sequence of human alpha-synuclein.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Primate
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$387.00Add to Cart

alpha Synuclein is a member of a family of small, highly conserved proteins, including synuclein-alpha, -beta, and -gamma, and synoretin. These proteins are localized predominantly in the brain, concentrated in presynaptic nerve terminals. Synuclein-alpha is normally a soluble protein. Abnormal synuclein-alpha forms filamentous inclusions (Lewy bodies and Lewy neurites) in several neurodegenerative diseases, including Parkinson's disease (PD), dementia with Lewy bodies, and Alzheimer¦s disease. It is a major component of intracellular inclusions in sporadic PD. Mutations in the synuclein-alpha gene (A53T and A30P) have been reported in several families with autosomal dominant Parkinsonism.

This antibody detects the alpha isoform of synuclein and may cross-react with beta-synuclein.

Image: Western blot analysis of extracts from 293, HeLa, rat brain and mouse brain cell extracts, using α-Synuclein Antibody.