Product Details
Catalog Number: RA19010
Applications: WB
Type: Rabbit IgG
Dilutions: WB 1:500
Immunogen: DGHGQDTSGQLP (a.a. 314-325 ) of the 40 kDa mouse HAP40 protein
Storage: Maintain at +2-8 degrees C for 3 months or at -20 degrees C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Mouse
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 uL$250.00Add to Cart

Huntington’s disease is caused by an expanded CAG trinucleotide repeat coding for a polyglutamine stretch within the huntingtin protein. Huntingtin co-purifies with a single novel 40 kDa protein designated HAP40. Recombinant HAP40 is cytoplasmic in the presence of huntingtin but is actively targeted to the nucleus in the absence of huntingtin. These observations suggest that HAP40 contributes to the function of normal huntingtin and is a candidate for involvement in the aberrant nuclear localization of mutant huntingtin found in degenerating neurons in Huntington’s disease.

Images

Product Image Unavailable