Shank is a novel family of postsynaptic density proteins (PSD) that bind to PSD-95-associated protein GKAP. Its putative function is to act as a scaffold protein in the PSD to cross-link NMDA receptors/PSD-95 complexes and couple them to regulators of the actin cytoskeleton. Shank1a is a splice variant of Shank1.
Shank1 A has also been found to be associated with L-type Ca2+ channels. Olson et al., J Neurosci. 2005, 25:1050-62; Zhang et al., J Neurosci. 2005, 25:1037-49) the same channels used by photoreceptors for transmitter release.
- Product Reviewseasy to order, get the right item and no delay. Thanks Neuromics. Product Name: SHANK1a C-terminus, Rabbit – (Cat# RA19016) http://bit.ly/1iZa4oV Organization: Johns Hopkins UniversityArij Cabrerachakir - Mar 19, 2015 - Rating: 4.0We are using antibodies for synaptic markers in the maturating inner ear. SHANK1 antibody from Neuromics one of the best markers for postsynaptic zone that are available and we are using this antibody a lot for two years now. Quality of antibodies also combines with fantastic service from the staff. Thank you! Product Name: SHANK1a C-Terminus (Cat# RA19016) http://bit.ly/1iZa4oV Organization: Stanford UniversityDiana Mendus - Oct 23, 2013 - Rating: 5.0
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- Product Publications
- Daniel O.J. Reijntjes, Christine Koppl, and Sonja J. Pyott. (2020). Volume Gradients in Inner Hair Cell-Auditory Nerve Fiber Pre- and Postsynaptic Proteins Differ Across Mouse Strains. Hearing Research. doi: 10.1016/j.heares.2020.107933
- Hanan Al‐Moyed, Andreia P Cepeda, SangYong Jung, Tobias Moser, Sebastian Kügler, Ellen Reisinger. (2018). A dual‐AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock‐out mice. Molecular Medicine. Volume 10, Issue 12. DOI 10.15252/emmm.201809396
- David R. Sultemeier, Kristel R. Choy, Felix E Schweizer, Larry F. Hoffman. (2017). Spaceflight-induced synaptic modifications within hair cells of the mammalian utricle. Journal of Neurophysiology, doi: 10.1152/jn.00240.2016
- Salvatore L. Stella Jr, Alejandro Vila, Albert Y. Hung, Michael E. Rome, Uyenchi Huynh, Morgan Sheng, Hans-Juergen Kreienkamp, Nicholas C. Brecha. (2012). Association of Shank 1A Scaffolding Protein with Cone Photoreceptor Terminals in the Mammalian Retina. PLoS ONE 7(9): e43463. doi: 10.1371/journal.pone.0043463
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