Product Details
Catalog Number: RA19021
Applications: WB
Type: Rabbit IgG
Dilutions: WB 1:500-1:1000
Immunogen: KKINYQVDSWE (a.a. 269-279) of the mouse PTCH protein.
Storage: Aliquot as undiluted antibody and immediately place at -20ºC. Working aliquot may be stored at +4-8ºC for up to 1 month. Liquid may have become trapped in top of vial during shipping. Centrifugation of vial is recommended before opening. Stable for at least 1 year at -20ºC. Repeated freeze/thaw cycles compromise the integrity of the antiserum.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$225.00Add to Cart

PTCH associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal.PTCH has a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. PTCH is expressed in the adult brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. It is also expressed in tumor cells but not in normal skin. During development PTCH is found in all major target tissues of sonic hedgehog, such as the ventral neural tube, somites, and tissues surrounding the zone of polarizing activity of the limb bud.

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