Product Details
Catalog Number: RA21001
Applications: IHC
Type: Rabbit IgG
Immunogen: YPWF conjugated to BSA
Format A: Affinity Purified
Format B: lyophilized
Species Reactivity: Human, Mouse, Rat, Primate
Downloads: Datasheet (pdf)
Product Sizes
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50 ug$155.00Add to Cart

Endomorphins are recently discovered endogenous opioid peptides composed of four amino acids: Endomorphin-1 (EM-1) is Tyr-Pro-Trp-Phe-NH2, and  Endomorphin-2 (EM-2) is Tyr-Pro-Phe-Phe-NH2. These peptides have a very high affinity and specificity for mu-opioid receptors as it has been reported in many pharmacological studies. EM-1 is distributed in many brain regions, whereas EM-2 is prevalent in brainstem and spinal cord.  EM-1 and EM-2 exert their antinociceptive activity by interacting with mu-opioid receptors. EM-1 anf EM-2 bind with mu-opioid receptor with high affinity and selectivity in comparison with binding to opioid delta and kappa receptors. EM-1 and EM-2 tetrapeptides activate G-proteins and inhibit adenylyl cyclase activity when bind to mu-opioid receptors.

Image:Endomorphin-1 staining in rat Peryaqueductal Grey Matter.

Note: Our affinity-purified anti EM-1 antibodies label neuronal fibers in various brain regions including (but not limited to) thalamic nuclei, periaqueductal gray matter, amygdala, locus coeruleus, nucleus accumbens, parabrachial nucleus, nucleus tractus solitarius and septum. Our affinity-purified anti-END-2 antibodiy labelsl neuronal processes in spinal cord dorsal horn and trigeminal tract, and label neuronal cell bodies in thalamus. END-1 and 2 distribution in brain overlaps with mu-opioid receptors.