Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999).
Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).
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Name Catalog # Size ATPase Na+/K+ transporting alpha 1 MO25023 50 ul KChIP1 K+ channel MO50011 100 ul KChIP2b K+ channel MO50012 100 ul Kir2.1 K+ channel MO50013 100 ul Kir2.2 K+ channel MO50014 100 ul Kv1.1 K+ channel MO50015 100 ul Kv1.2 K+ channel MO50016 100 ul Kv1.3 K+ channel MO50017 100 ul Kv1.4 K+ channel MO50018 100 ul Kv2.1 K+ channel MO50019 100 ul Kv3.1b K+ channel MO50020 100 ul Kv4.2 K+ channel MO50021 100 ul Kv7.1/KCNQ1 K+ channel MO50022 100 ul Kv7.2/KCNQ2 K+ channel MO50023 100 ul TREK 1 RA25018 100 ul