Product Details
Catalog Number: RA25029
Applications: WB
Type: Rabbit IgG
Immunogen: Peptide corresponding to residues surrounding Thr668 of human APP695
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$295.00Add to Cart

Amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer's disease (AD). FE65 is a signaling adaptor of APP protein. The FE65/APP complex was shown to translocate into the cell nucleus and regulate gene expression. Genetic studies in mice validated FE65-APP interaction and molecular studies provided evidence on the role of the complex in abnormal signaling detected in brains of Alzheimer Disease patients.

Image: Western blot analysis using FE65 and HEK 293 cell lysates

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Images