Product Details
Catalog Number: RA25037
Applications: WB, IHC, IP
Type: Rabbit IgG
Immunogen: C-terminal fusion protein representing amino acids 1253 - 1391of rat NMDAR2A.
Format A: Whole serum
Format B: lyophilized
Species Reactivity: Human, Rat
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$425.00Add to Cart

N-methyl-D-aspartate receptor (NMDAR) forms a heterodimer of at least one NR1 and one NR2A-D subunit. Multiple receptor isoforms with distinct brain distributions and functional properties arise by selective splicing of the NR1 transcripts and differential expression of the NR2 subunits. NR1 subunits bind the co-agonist glycine and NR2 subunits bind the neurotransmitter glutamate.

NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.

Image: NMDAR2A Western Blot Analysis:

Lane 1: Rat Hippocampus
Lane 2: HEK cells transfected with NMDA NR2A
Lane 3: HEK cells transfected with NMDA NR2B
Lane 4: HEK cells transfected with NMDA NR2C
Lane 5: same as Lane 2 but antibody preabsorbed with NMDA NR2A