Product Details
Catalog Number: RA26001
Applications: WB, IHC
Type: Rabbit IgG
Immunogen: C-terminal sequence of human Mitofusion 2
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Rabbit
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$375.00Add to Cart

Mitofusion 2  or MFN2 is an essential transmembrane GTPase which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton, plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. It plays an important role in the regulation of vascular smooth muscle cell proliferation. Defects in MFN2 lead to Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system.

Images: Top: MFN2 staining of paraffin-embedded rat cardiac muscle tissue. Bottom: Detection of MFN2 from rat cardiac muscle tissue lysate by Western blot.

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