The Frizzled 7 (FZD7) protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Frizzled family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. Frizzled 7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. Frizzled 7 expression has been reported in brain, gastrointestinal tract, heart, fetal kidney, fetal lung, placenta, skeletal muscle, and various cancers. ESTs have been isolated from a wide variety of normal and cancer libraries.
Image: FZD7 staining of Human Heart Tissue. Formalin-Fixed Paraffin-Embedded (FFPE).
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Name Catalog # Frizzled 4/CD344 GT15217 Vasopressin V1B Receptor GT41005 Corticotropin Releasing Hormone Receptor 1 GT41006 Vasopressin V1B Receptor GT41021 APJ (Apelin Receptor) MO15011 Somatostatin Receptor-2-SSTR2 MO15109 Rhodopsin (B630) MO22127 Rhodopsin (A531) MO22128 Orphanin FQ/Nociceptin RA10106 Alpha 2a Adrenergic Receptor RA14110 Bradykinin Receptor B2 RA14137 Alpha 2c Adrenergic Receptor RA19064 Oxytocin RA24604 Somatostatin Receptor-1-SSTR1 RA25004 Somatostatin Receptor-2-SSTR2 RA25005 GPR49 RA25071 Frizzled 9 RA30032 GPR3 RA30048 GPRC6A RA30049 GPR12 RA30050