Product Details
Catalog Number: RA30051
Applications: IHC
Type: Rabbit IgG
Immunogen: KLH conjugated synthetic peptide- 23 amino acids from near the amino terminus of human neurotrypsin.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Downloads: Datasheet (pdf)
Product Sizes
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50 ug$435.00Add to Cart

The synaptic serine protease neurotrypsin is thought to be important for adaptive synaptic processes required for cognitive functions. Truncation or absence of Neurotrypsin causes severe mental retardation.

 It is most prominently expressed in the cerebral cortex, the hippocampus, and amygdala. Evidence suggests that neurotrypsin has multiple functions, including axonal outgrowth, maintaining neuronal plasticity, and arranging the perineuronal environment, partly in coordination with other proteases including tissue plasminogen activator.

Image: Neurotrypsin staining of  Human Cerebellum (formalin-fixed, paraffin-embedded) at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Protocol on data-sheet.