The main function of fibroblasts is to maintain the structural integrity of connective tissues by continuously secreting precursors of the extracellular matrix. Like other cells of connective tissue, fibroblasts are derived from primitive mesenchyme. Thus they express the intermediate filament protein vimentin, a feature used as a marker to distinguish their mesodermal origin. In addition forming and maintaining extracellular matrices, they also regulate interstitial fluid volume and pressure, and wound healing. Many diseases are associated with dysregulation of the injury repair response and fibroblast function, leading to increased or decreased deposition of extracellular matrix proteins, altered tissue architecture, impaired function and in some cases significant morbidity and mortality. This includes association with cancer cells at all stages of cancer progression.

  • Cancer Associated Fibroblasts (CAFs)

    CAFs are closely associated with primary tumor cells and participate in the neoplastic process. There is reciprocal communication between CAFs and tumor cells through paracrine effects of secreted growth factors, cytokines & chemokines from both fibroblasts, tumor cells and other tumor-associated cells. CAFs are potential target for cancer therapy and enhanced understanding of tumor growth, angiogenesis and metastasis.

    Name Catalog # Type Species Applications Size Price
    CAF08 Human Primary CAFs Human Cell Assays 1,000,000 Immortized Cells $1,550.00
    Human Breast CAFs CAF06 Human Primary CAFs Human Cell Assays 1,000,000 cells $1,955.00
    Human Colorectal Tumor CAFs CAF05 Human Primary CAFs Human Cell Assays 1,000,000 cells $799.00
    Human Endometrial Adenocarcinoma CAFs CAF01 Human Primary CAFs Human Cell Assays 1,000,000 cells $799.00
    Human Immortalized Pancreatic CAF-Stellate Cells CAF08 Human Primary CAFs Human Cell Assays 1,000,000 Immortized Cells $1,550.00
    Human Lung Adenocarcinoma CAFs CAF07A Human Primary CAFs Human Cell Assays 1,000,000 cells $815.00
    Human Lung Squamous Cell Tumor CAFs CAF07SC Human Primary CAFs Human Cell Assays 1,000,000 cells $815.00
    Human Melanoma CAFs CAF09 Human Primary CAFs Human Cell Assays 1,000,000 cells $899.00
    Human Ovarian Serous Tumor CAFs CAF02 Human Primary CAFs Human Cell Assays 1,000,000 cells $799.00
  • Human Fibroblasts

    These human fibroblast cells are suitable for use in derivation of iPS cells and other applications requiring human fibroblasts including vaccine production and studies of cancer-associated fibroblasts (CAFs).

    Name Catalog # Type Species Applications Size Price
    Human Fibroblasts-GFP Expressing GFP07 Primary Cells Human Cell Assays 500,000 Cells in T25 flask $999.00
    Native Human Fibroblasts SC00A5 Primary Cells Human Cell Assays 500,000 Cells $555.00
  • Media for Fibroblast and CAFs

    Media for Fibroblasts and CAFs

    Name Catalog # Type Species Applications Size Price
    Pancreatic Stellate CAF Maintaining Media PC00B5-500 Cell Growth Media Human Cell Assays 500 ml $208.00
    VitroPlus III, low serum, complete PC00B1-500 Cell Growth Media Human Cell Assays 500 ml $205.00