Pancreatic cancer remains one of the most deadly and least survivable cancers; it is asymptomatic until quite advanced and is resistant to conventional therapies. It has recently become apparent that cancer tumor cells are closely associated with other cells called cancer-associated fibroblasts or CAFs. These cells promote the malignant process and block immune surveillance. CAFs are thus new drug targets for pancreatic and other cancer therapies. Our products were used in recent research regarding pancreatic stellate cells, a CAF that is gaining considerable interest for new treatment options through advanced understanding of cancer biology.
These cells should be cultured with Pancreatic Stellate CAF Maintaining Media and we highly recommend culturing these cells in reduced O2 levels (1% to 5% O2).
Product is manufactured, tested and validated in an ISO 9001/ISO13485/CLIA certified facility.
- Product ReviewsI ordered a vial of pancreatic CAFs, the customer service was very good and they always answered our emails in a short period of time. I give 4 stars because I just think that the prices are high, but the overall experience is 5 stars :)Gabriela Vázquez Rodríguez - Jun 24, 2021 - Rating: 4.0
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- Product Publications
- Georgia Papaparaskeva, Maria Louca, Chrysovalantis Voutouri, Eugenia Tanasa, Triantafyllos Stylianopoulos, and Theodora Krasia-Christoforou. (2020). Amalgamated Fiber/Hydrogel Composites Based on Semi-Interpenetrating Polymer Networks and Electrospun Nanocomposite Fibrous Mats. European Polymer Journal, 140:110041. doi: 10.1016/j.eurpolymj.2020.110041
- Aleksandra Adamska, Alice Domenichini, Emily Capone, Verena Damiani, Begum Gokcen Akkaya, Kenneth J. Linton, Pierluigi Di Sebastiano, Xi Chen, Adam B. Keeton, Veronica Ramirez-Alcantara, Yulia Maxuitenko, Gary A. Piazza, Vicenzo De Laurenzi, Gianluca Sala, and Marco Falasca. (2019). Pharmacological Inhibition of ABCC3 Slows Tumour Progression in Animal Models of Pancreatic Cancer. Journal of Experimental and Clinical Cancer Research, 38:312. doi: 10.1186/s13046-019-1308-7
- Andreas Stylianou, Vasiliki Gkretsi, Maria Louca, Lefteris C. Zacharia, and Triantafyllos Stylianopoulos (2019). Collagen content and extracellular matrix cause cytoskeletal remodelling in pancreatic fibroblasts. J. R. Soc. Interface 16: 20190226. http://dx.doi.org/10.1098/rsif.2019.0226
- Stylianou, Andreas & Gkretsi, Vasiliki & Stylianopoulos, Triantafyllos. (2018). Transforming growth factor-β modulates pancreatic cancer associated fibroblasts cell shape, stiffness and invasion. Biochimica et biophysica acta. 1862. 10.1016/j.bbagen.2018.02.009.
- Zenobia D'Costa, Keaton Jones, Abul Azad, Ruud van Stiphout, Su Y Lim, Ana L Gomes, Paul Kinchesh, Sean C Smart, W. Gillies McKenna, Francesca M Buffa, Owen J. Sansom, Ruth J. Muschel, Eric O'Neill and Emmanouil Fokas. (2017). Gemcitabine-induced TIMP1 attenuates therapy response and promotes tumor growth and liver metastasis in pancreatic cancer. doi: 10.1158/0008-5472.CAN-16-2833
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