Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5. Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies.
- Product Reviews
- Product Publications
- Roy B, Jackson GR. (2014). Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease. Hum Mol Genet. 23(11):3008-23. doi: 10.1093/hmg/ddu011
If you've used this product in a publication, let us know. Email firstname.lastname@example.org, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size Human LC3A Antibody MO15167 100 ug Human LC3A Antibody MO15168 100 ug MAP2 CH23032 100 ul MAP2 GT22102 100 ul MAP2 (Microtubule assoc. protein 2) CH22103 50 ul MAP2 (Microtubule assoc. protein 2) MO22116 100 ul MAP2 (Microtubule assoc. protein 2) MO30000 50 ul Tau (Tau 46) MO18002 100 ul Tau /MAPT+ CH22113 100 ul