Product Details
Catalog Number: GT41000
Applications: WB, IHC, E
Type: Goat IgG
Immunogen: Purified, E. coli-derived, recombinant human Mothers Against DPP homolog 1 (rhSmad1; aa 2 - 454).
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human
Entrez: 326
UniProt: O43918
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$325.00Add to Cart

AIRE is a transcriptional regulator that is thought to be important in controlling tissue-specific expression of genes in the thymus. The precise function of the protein is not well defined. It contains zinc finger motifs. The AIRE isoform 1 (AIRE) is a splice variant and is localized to both the nucleus and cytoplasm.

Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).

Images
AIRE 1 staining (dilution: 0.05µg/ml) of HEK293 cell lysates. Untransfected (Lane 3) and transfected with Human AIRE1 (lane 4). Data kindly provided by Prof. Pärt Peterson, University of Tartu, Estonia.

AIRE 1 staining (dilution: 0.05µg/ml) of HEK293 cell lysates. Untransfected (Lane 3) and transfected with Human AIRE1 (lane 4). Data kindly provided by Prof. Pärt Peterson, University of Tartu, Estonia.

AIRE 1 staining (dilution: 0.05µg/ml) of HEK293 cell lysates. Untransfected (Lane 3) and transfected with Human AIRE1 (lane 4). Data kindly provided by Prof. Pärt Peterson, University of Tartu, Estonia.

AIRE 1 staining (dilution: 0.05µg/ml) of HEK293 cell lysates. Untransfected (Lane 3) and transfected with Human AIRE1 (lane 4). Data kindly provided by Prof. Pärt Peterson, University of Tartu, Estonia.

AIRE1  staining (dilution: 2.5µg/ml) of paraffin embedded Human Thymus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

AIRE1 staining (dilution: 2.5µg/ml) of paraffin-embedded Human Thymus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

AIRE1  staining (dilution: 2.5µg/ml) of paraffin embedded Human Thymus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

AIRE1 staining (dilution: 2.5µg/ml) of paraffin-embedded Human Thymus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.