GABAA receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds, because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics.
Defects in GABA A Receptor beta 3 (GABRB3) is associated with chronic insomnia and childhood absence epilepsy type 5 (ECA5).
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