NOS1AP or Capon is an adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. It competes with PSD95 for interaction with nNOS, and overexpression results in a loss of PSD95/nNOS complexes in transfected cells. CAPON may influence nNOS by regulating its ability to associate with PSD95/NMDA receptor complexes.
Coding variation in the NOS1AP gene could increase susceptibility to psychiatric disorders like schizophrenia and autism spectrum disorders (ASDs) and obsessive-compulsive disorder (OCD).
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email firstname.lastname@example.org, with the publication details and you could be eligible for an Amazon gift card.
- Related Products