NOS1AP or Capon is an adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. It competes with PSD95 for interaction with nNOS, and overexpression results in a loss of PSD95/nNOS complexes in transfected cells. CAPON may influence nNOS by regulating its ability to associate with PSD95/NMDA receptor complexes.
Coding variation in the NOS1AP gene could increase susceptibility to psychiatric disorders like schizophrenia and autism spectrum disorders (ASDs) and obsessive-compulsive disorder (OCD).
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