Product Details
Catalog Number: GT41024
Applications: WB, IHC
Type: Goat IgG
Immunogen: Peptide with sequence C-KIKSGERGRKG, from the internal region of the Neurogranin precursor protein sequence according to NP_006167.1.
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 4900
UniProt: Q92686
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ug$335.00Add to Cart

Neurogranin is a calmodulin-binding protein expressed exclusively in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway. Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the absence of calcium. Phosphorylation by protein kinase C lowers its binding ability

Neurogranin is downregulate in Schizophrenia and is not found in the dendrites in patients with Alzheimer disease.

Images
Neurogranin precursor (dilution: 0.1µg/ml) staining of Mouse Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Neurogranin precursor (dilution: 0.1µg/ml) staining of Mouse Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Neurogranin precursor (dilution: 0.1µg/ml) staining of Mouse Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Neurogranin precursor (dilution: 0.1µg/ml) staining of Mouse Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Neurogranin (dilution: 4.0 µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Protocol on data-sheet.

Neurogranin (dilution: 4.0 µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Protocol on data-sheet.

Neurogranin (dilution: 4.0 µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Protocol on data-sheet.

Neurogranin (dilution: 4.0 µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Protocol on data-sheet.