Members of the semaphorin protein family are involved in axonal guidance during neural development. Semaphorin 5a is thought to have a bifunctional role in axon guidance, exerting both attractive and inhibitory effects on developing axons associated with limbic function. The thrombospondin repeats of Semaphorin 5a physically interact with both heparan sulfate proteoglycans and chondroitin sulfate proteoglycans, inducing attractive and inhibitory guidance cues, respectively. The biological responses to Semaphorin 5a are induced through binding to its high-affinity receptor, plexin B3, triggering intracellular signaling through Me
Semaphorine 5A plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions
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Name Catalog # Size Plexin A3 GT15211 100 ug Semaphorin 3B RA25088 50 ul Semaphorin 3C GT15077 100 ug Semaphorin 6a GT15056 100 ug Semaphorin 6a MO15023 100 ug Semaphorin 6a MO15023 50 ug Semaphorin 6a MO15023 500 ug Semaphorin 6B GT15165 100 ug Semaphorin 7A GT15076 50 ug Semaphorin 7A MO15041 100 ug Semaphorin 7A MO15041 50 ug Semaphorin 7A MO15041 500 ug