Product Details
Catalog Number: GT41028
Applications: WB, IHC, IP
Type: Goat IgG
Immunogen: Peptide with sequence DSGNHCFKVYRYLQ, from the C Terminus of the TRIM2 protein sequence according to NP_056086.2; NP_001123539.1
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 23321
UniProt: Q9C040
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ug$325.00$250.00Add to Cart

TRIM RING finger protein TRIM2, a ubiquitin ligase, is highly expressed in the nervous system. It binds to neurofilament light subunit (NF-L);and regulates NF-L ubiquitination. Deficiencies in TRIM2 increases NF-L level in axons and NF-L-filled axonal swellings in cerebellum, retina, spinal cord, and cerebral cortex.

These deficiencies eventually lead to neurodegeneration, tremors and ataxia. It is proposed that TRIM2 has neuroprotection properties.

Supporting Products
NameCatalog #Size
TRIM2P41028100 ug Blocking Peptide
Images
TRIM2 (dilution: 6.3 µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Note cytoplasm staining in neuronal cell bodies. Protocol on datasheet.

TRIM2 (dilution: 6.3 µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Note cytoplasm staining in neuronal cell bodies. Protocol on datasheet.

TRIM2 (dilution: 6.3 µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Note cytoplasm staining in neuronal cell bodies. Protocol on datasheet.

TRIM2 (dilution: 6.3 µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Note cytoplasm staining in neuronal cell bodies. Protocol on datasheet.

TRIM2 (dilution: 0.5 µg/ml) staining of Rat Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

TRIM2 (dilution: 0.5 µg/ml) staining of Rat Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

TRIM2 (dilution: 0.5 µg/ml) staining of Rat Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

TRIM2 (dilution: 0.5 µg/ml) staining of Rat Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.