TRPM7 (Transient receptor potential cation channel, subfamily M, member 7) is a divalent cation channel permeable to calcium and magnesium. It has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death.
Defects in TRPM7 are a cause of susceptibility to amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 (ALS-PDC1).
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