Product Details
Catalog Number: MO25010
Applications: WB, IHC, E
Type: Mouse IgG
Immunogen: Native PGP 9.5 protein from brain.
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Bovine, Porcine
Entrez: 7345
UniProt: P09936
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$614.00Add to Cart

PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl-terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers.

It was also discovered as a gene mutated in some rare familial forms of Parkinson's disease. Interestingly a common allelic variant of UCHL1, the S18Y polymorphism is actually protective against Parkinson's disease. It is also a marker for cells of the diffuse neuroendocrine system and their tumors.

Images

The PGP mouse that we received from Neuromics works fantastically! I used it at 1:100 with Cy3 at 1:500 and got great staining with good background levels. PGP9.5 staining of Rat Abdominal Tissue. Courtesy of Jamie Nugent (Dr. Marna Ericson's Lab), University of Minnesota.

The PGP mouse that we received from Neuromics works fantastically! I used it at 1:100 with Cy3 at 1:500 and got great staining with good background levels. PGP9.5 staining of Rat Abdominal Tissue. Courtesy of Jamie Nugent (Dr. Marna Ericson's Lab), University of Minnesota.